| ncRNA name | HIF-1α shRNA |
| ncRNA Category | shRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | human UM cell lines OCM1, Mel285, Mel290, 92.1 and OMM1 |
| Methods | shRNA knockdown, qPCR, Western blot, MTS colorimetric assay, transwell assay, immunohistochemistry |
| Expression pattern | associated |
| Functional description | HIF-1α knockdown using shRNA significantly decreased growth in hypoxia, and reduced by more than 50% tumor invasion in four lines with high HIF-1α baseline levels. |
| PubMed ID | 25166211 |
| Year | 2014 |
| Title | Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. |
| Drug-related ncRNA | NA |
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